01 · Cellular Renewal
The 28-day cycle
Skin renews its outermost layer roughly every 28 days. Our protocol times bio-active peptides and hydration windows to this rhythm so ingredients arrive when cells are most receptive to signaling.
The Science
Selene is built on peer-reviewed dermal science, clinically dosed peptides, and the 28-day cadence of cellular renewal. Every ingredient earns its place through dose, absorption, and evidence — not narrative.
01 · Cellular Renewal
Skin renews its outermost layer roughly every 28 days. Our protocol times bio-active peptides and hydration windows to this rhythm so ingredients arrive when cells are most receptive to signaling.
02 · Bio-availability
Peptides are delivered at sizes small enough to cross the barrier and register at their target receptors. Hyaluronic acid is used in low and high molecular weights, and GHK-Cu is dosed within the clinically studied topical range.
03 · Regenerative Signaling
GHK-Cu is a naturally occurring tripeptide that declines ~60% between age 20 and 60. In clinical work it up-regulates collagen and elastin synthesis, supports antioxidant defenses, and improves skin firmness and clarity when applied topically.
04 · Barrier-First Protocol
Density is a barrier outcome. A pH-balanced cleanse restores the acid mantle, targeted actives modulate pigment and signaling, and a peptide-retinoid cream directs overnight repair. Layered, they compound.
The Dossier
GHK-Cu Copper Peptide
1%
Regenerative signaling
Palmitoyl Tripeptide-1
0.5%
Collagen support
Palmitoyl Tetrapeptide-7
0.5%
Anti-inflammatory
Acetyl Hexapeptide-8
5%
Expression-line smoothing
Ectoin
1%
Cellular hydration + protection
Niacinamide (Vitamin B3)
5%
Barrier + tone
Tranexamic Acid
3%
Pigment modulator
Alpha Arbutin
2%
Melanin inhibition
Ceramide NP / AP / EOP
1%
Lamellar lipid repair
Hyaluronic Acid (Na-hyaluronate)
1–2%
Moisture reservoir
The Method
Skin is a downstream tissue. What arrives in the dermis — amino acids, minerals, signaling peptides — comes from what circulates. Selene's daily rituals feed the substrate; the topical layer directs it.
The four phases of the 28-day skin cycle — renewal, hydration, resilience, repair — each call for a different active. Every formula is dosed for the phase it serves.
References
Every claim above traces to published, peer-reviewed work. Follow the DOI or full-text link to read the source yourself.
Pickart L, Vasquez-Soltero JM, Margolina A. GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. Biomed Res Int. 2015;2015:648108.
Source ↗Full text ↗DOI: 10.1155/2015/648108
Bissett DL, Oblong JE, Berge CA. Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31(7 Pt 2):860–865.
Source ↗Full text ↗DOI: 10.1111/j.1524-4725.2005.31732
Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: a key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253–258.
Source ↗Full text ↗DOI: 10.4161/derm.21923
Kim HJ, Moon SH, Cho SH, Lee JD, Kim HS. Efficacy and safety of tranexamic acid in melasma: a meta-analysis and systematic review. Acta Derm Venereol. 2017;97(7):776–781.
Source ↗Full text ↗DOI: 10.2340/00015555-2668
Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006;1(4):327–348.
Source ↗Full text ↗DOI: 10.2147/ciia.2006.1.4.327
Quality standards
Our products are made in a facility that maintains the credentials below at the facility level. These are manufacturing standards — not product-specific certifications or claims about individual formulas.